2c7v Summary details

pdbe.org/2c7v/summary_details
spacer STRUCTURE OF TRYPANOSOMA BRUCEI PTERIDINE REDUCTASE (PTR1) IN TERNARY COMPLEX WITH COFACTOR AND THE ANTIFOLATE METHOTREXATE
Summary
Header OXIDOREDUCTASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.2 Å, R-factor: 15.7%, Free R-factor: 22.3%, Spacegroup: P 1 21 1
Released 19/09/2006, deposition: 29/11/2005, last revision: 24/02/2009
Authors Dawson, A.search; Gibellini, F.search; Sienkiewicz, N.search; Fyfe, P.K.search; Mcluskey, K.search; Fairlamb, A.H.search; Hunter, W.N.search
Primary citation Structure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition by the Archetypal Antifolate Methotrexate
MOL.MICROBIOL.search vol:61, pag:1457 (2006) [PubMed 16968221 ]search
Keywords PTERIDINE REDUCTASEsearch, TRYPANOSOMATIDSsearch, DRUG RESISTANCEsearch, SHORT-CHAIN DEHYDROGENASE/REDUCTASEsearch, METHOTREXATE RESISTANCEsearch, OXIDOREDUCTASEsearch
EC 1.5.1.33 ExPASy BRENDA search (A B C D)
Organism Trypanosoma brucei brucei 5702search(A B C D)
UniProt O76290search (A B C D)
Solvent A, B, C, D
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A, B, C, D PTERIDINE REDUCTASE Protein O76290 (O76290_TRYBB)search
268 97%
Heterogens
Chain Id Name Ligands
A, B, C, D NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE NAP search
A, B, C, D METHOTREXATE MTX search
A, B NICKEL (II) ION NI search
A, B ACETATE ION ACT search
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