2c7v Summary

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STRUCTURE OF TRYPANOSOMA BRUCEI PTERIDINE REDUCTASE (PTR1) IN TERNARY COMPLEX WITH COFACTOR AND THE ANTIFOLATE METHOTREXATE

The structure was published by Dawson, A., Gibellini, F., Sienkiewicz, N., et al., Mcluskey, K., Fairlamb, A.H., and Hunter, W.N., in 2006 in a paper entitled "Structure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition by the Archetypal Antifolate Methotrexate" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PTERIDINE REDUCTASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PTERIDINE REDUCTASE O76290 (1-268) (O76290_TRYBB)search Trypanosoma brucei bruceisearch 100% 268 97%
B PTERIDINE REDUCTASE O76290 (1-268) (O76290_TRYBB)search Trypanosoma brucei bruceisearch 100% 268 97%
C PTERIDINE REDUCTASE O76290 (1-268) (O76290_TRYBB)search Trypanosoma brucei bruceisearch 100% 268 97%
D PTERIDINE REDUCTASE O76290 (1-268) (O76290_TRYBB)search Trypanosoma brucei bruceisearch 100% 268 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O76290 (1 - 268) PTERIDINE REDUCTASE Trypanosoma brucei brucei

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (O76290) NAD(P)-binding Rossmann-like Domainsearch PF13561: Enoyl-(Acyl carrier protein) reductasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B, C, D (O76290) nucleotide bindingsearch oxidoreductase activitysearch metabolic processsearch oxidation-reduction processsearch

Chain InterPro annotation
A, B, C, D Short-chain dehydrogenase/reductase SDRsearch Glucose/ribitol dehydrogenasesearch Pteridine reductasesearch NAD(P)-binding domainsearch Short-chain dehydrogenase/reductase, conserved sitesearch