2c76 Summary

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FUNCTIONAL ROLE OF THE AROMATIC CAGE IN HUMAN MONOAMINE OXIDASE B: STRUCTURES AND CATALYTIC PROPERTIES OF TYR435 MUTANT PROTEINS

The structure was published by Li, M., Binda, C., Mattevi, A., and Edmondson, D.E., in 2006 in a paper entitled "Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of AMINE OXIDASE (FLAVIN-CONTAINING) B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AMINE OXIDASE (FLAVIN-CONTAINING) B P27338 (2-520) (AOFB_HUMAN)search Homo sapienssearch 100% 520 95%
B AMINE OXIDASE (FLAVIN-CONTAINING) B P27338 (2-520) (AOFB_HUMAN)search Homo sapienssearch 100% 520 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P27338 (2 - 520) AMINE OXIDASE (FLAVIN-CONTAINING) B Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P27338) FAD-linked reductases, N-terminal domainsearch, L-aminoacid/polyamine oxidasesearch FAD/NAD(P)-binding domainsearch, Polyamine Oxidase; Chain A, domain 2search, Guanine Nucleotide Dissociation Inhibitor, domain 1search PF01593: Flavin containing amine oxidoreductasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P27338) small molecule metabolic processsearch response to selenium ionsearch response to steroid hormonesearch oxidation-reduction processsearch response to corticosteronesearch response to toxic substancesearch substantia nigra developmentsearch xenobiotic metabolic processsearch response to lipopolysaccharidesearch positive regulation of dopamine metabolic processsearch response to ethanolsearch response to aluminum ionsearch response to drugsearch negative regulation of serotonin secretionsearch mitochondrial outer membranesearch mitochondrial envelopesearch mitochondrionsearch integral component of membranesearch mitochondrial inner membranesearch membranesearch extracellular vesicular exosomesearch electron carrier activitysearch oxidoreductase activitysearch protein homodimerization activitysearch primary amine oxidase activitysearch flavin adenine dinucleotide bindingsearch

Chain InterPro annotation
A, B Flavin amine oxidasesearch Amine oxidasesearch