2c6t Summary

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CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR

The structure was published by Richardson, C.M., Williamson, D.S., Parratt, M.J., et al., Robertson, A., Surgenor, A.E., and Torrance, C.J., in 2006 in a paper entitled "Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.61 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
B CYCLIN A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%
D CYCLIN A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (175 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P24941) ATP bindingsearch protein kinase activitysearch protein bindingsearch histone kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch metal ion bindingsearch kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch cyclin bindingsearch nucleotide bindingsearch endosomesearch nucleussearch nucleoplasmsearch Y chromosomesearch cytosolsearch centrosomesearch cytoskeletonsearch X chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch transcription factor complexsearch cytoplasmsearch chromosome, telomeric regionsearch condensed chromosomesearch microtubule organizing centersearch Cajal bodysearch G2/M transition of mitotic cell cyclesearch DNA replicationsearch G1/S transition of mitotic cell cyclesearch protein phosphorylationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch cellular response to DNA damage stimulussearch phosphorylationsearch mitotic G1 DNA damage checkpointsearch centrosome duplicationsearch DNA repairsearch positive regulation of cell proliferationsearch meiotic nuclear divisionsearch positive regulation of DNA-dependent DNA replication initiationsearch regulation of gene silencingsearch mitotic nuclear divisionsearch cellular response to nitric oxidesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cell divisionsearch mitotic cell cyclesearch potassium ion transportsearch histone phosphorylationsearch Ras protein signal transductionsearch blood coagulationsearch cell cyclesearch meiotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch
B, D (P20248) protein kinase bindingsearch nucleussearch regulation of cell cyclesearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/F/Osearch Cyclin A, chordatessearch