2c6o Summary

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CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR

The structure was published by Richardson, C.M., Williamson, D.S., Parratt, M.J., et al., Robertson, A., Surgenor, A.E., and Torrance, C.J., in 2006 in a paper entitled "Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 288 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch transferase activitysearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch nucleotide bindingsearch cyclin bindingsearch histone kinase activitysearch metal ion bindingsearch protein phosphorylationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch potassium ion transportsearch DNA replicationsearch meiotic nuclear divisionsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch G2/M transition of mitotic cell cyclesearch cellular response to DNA damage stimulussearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch positive regulation of cell proliferationsearch centrosome duplicationsearch cell divisionsearch positive regulation of DNA-dependent DNA replication initiationsearch positive regulation of transcription, DNA-templatedsearch DNA repairsearch cell cyclesearch mitotic cell cyclesearch Ras protein signal transductionsearch histone phosphorylationsearch mitotic nuclear divisionsearch G1/S transition of mitotic cell cyclesearch blood coagulationsearch regulation of gene silencingsearch phosphorylationsearch cellular response to nitric oxidesearch mitotic G1 DNA damage checkpointsearch nucleoplasmsearch nucleussearch cytoplasmsearch cytoskeletonsearch Cajal bodysearch chromosome, telomeric regionsearch transcription factor complexsearch condensed chromosomesearch endosomesearch cytosolsearch microtubule organizing centersearch cyclin-dependent protein kinase holoenzyme complexsearch Y chromosomesearch centrosomesearch X chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch