2c6l Summary

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CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR

The structure was published by Richardson, C.M., Williamson, D.S., Parratt, M.J., et al., Robertson, A., Surgenor, A.E., and Torrance, C.J., in 2006 in a paper entitled "Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 290 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch transferase activitysearch protein bindingsearch kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch histone kinase activitysearch cyclin bindingsearch metal ion bindingsearch nucleotide bindingsearch protein phosphorylationsearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic nuclear divisionsearch G2/M transition of mitotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch potassium ion transportsearch cell cyclesearch meiotic nuclear divisionsearch phosphorylationsearch DNA replicationsearch histone phosphorylationsearch positive regulation of transcription, DNA-templatedsearch mitotic G1 DNA damage checkpointsearch mitotic cell cyclesearch Ras protein signal transductionsearch mitotic G2 phasesearch cell divisionsearch centrosome duplicationsearch cellular response to nitric oxidesearch DNA repairsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch G1/S transition of mitotic cell cyclesearch blood coagulationsearch positive regulation of cell proliferationsearch regulation of gene silencingsearch cellular response to DNA damage stimulussearch nucleoplasmsearch endosomesearch centrosomesearch nucleussearch X chromosomesearch cytoskeletonsearch cyclin-dependent protein kinase holoenzyme complexsearch condensed chromosomesearch Cajal bodysearch Y chromosomesearch microtubule organizing centersearch cytosolsearch cytoplasmsearch chromosome, telomeric regionsearch transcription factor complexsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch