2c6e Summary



The structure was published by Heron, N.M., Anderson, M., Blowers, D.P., et al., Pink, J., Roberts, N.J., and Rowsell, S., in 2006 in a paper entitled "Sar and Inhibitor Complex Structure Determination of a Novel Class of Potent and Specific Aurora Kinase Inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of SERINE/THREONINE-PROTEIN KINASE 6.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SERINE/THREONINE-PROTEIN KINASE 6 O14965 (123-401) (AURKA_HUMAN)search Homo sapienssearch < 90% 283 88%
B SERINE/THREONINE-PROTEIN KINASE 6 O14965 (123-401) (AURKA_HUMAN)search Homo sapienssearch < 90% 283 88%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14965 (123 - 401) SERINE/THREONINE-PROTEIN KINASE 6 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (O14965) ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch