2c69 Summary

pdbe.org/2c69
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CRYSTAL STRUCTURE OF THE HUMAN CDK2 COMPLEXED WITH THE TRIAZOLOPYRIMIDINE INHIBITOR

The structure was published by Richardson, C.M., Williamson, D.S., Parratt, M.J., et al., Robertson, A., Surgenor, A.E., and Torrance, C.J., in 2006 in a paper entitled "Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 291 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch cyclin-dependent protein serine/threonine kinase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch nucleotide bindingsearch cyclin bindingsearch histone kinase activitysearch kinase activitysearch metal ion bindingsearch transferase activitysearch protein phosphorylationsearch DNA replicationsearch blood coagulationsearch histone phosphorylationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cell divisionsearch meiotic nuclear divisionsearch G1/S transition of mitotic cell cyclesearch cellular response to nitric oxidesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch regulation of gene silencingsearch G2/M transition of mitotic cell cyclesearch positive regulation of DNA-dependent DNA replication initiationsearch phosphorylationsearch Ras protein signal transductionsearch centrosome duplicationsearch cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch cellular response to DNA damage stimulussearch positive regulation of cell proliferationsearch DNA repairsearch positive regulation of transcription, DNA-templatedsearch potassium ion transportsearch mitotic nuclear divisionsearch mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch nucleoplasmsearch Cajal bodysearch cytoplasmsearch transcription factor complexsearch chromosome, telomeric regionsearch cyclin-dependent protein kinase holoenzyme complexsearch nucleussearch cytoskeletonsearch endosomesearch centrosomesearch X chromosomesearch microtubule organizing centersearch cytosolsearch Y chromosomesearch condensed chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch