2c5y Summary



The structure was published by Kontopidis, G., Mcinnes, C., Pandalaneni, S.R., et al., Wang, S., Walkinshaw, M.D., and Fischer, P.M., in 2006 in a paper entitled "Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 290 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch metal ion bindingsearch histone kinase activitysearch cyclin bindingsearch nucleotide bindingsearch transferase activitysearch kinase activitysearch protein phosphorylationsearch mitotic G1 DNA damage checkpointsearch centrosome duplicationsearch phosphorylationsearch G2/M transition of mitotic cell cyclesearch DNA replicationsearch meiotic cell cyclesearch meiotic nuclear divisionsearch positive regulation of transcription, DNA-templatedsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cellular response to DNA damage stimulussearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch DNA repairsearch cell cyclesearch regulation of gene silencingsearch histone phosphorylationsearch cellular response to nitric oxidesearch blood coagulationsearch mitotic cell cyclesearch Ras protein signal transductionsearch G1/S transition of mitotic cell cyclesearch mitotic nuclear divisionsearch cell divisionsearch positive regulation of cell proliferationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch potassium ion transportsearch positive regulation of DNA-dependent DNA replication initiationsearch nucleoplasmsearch endosomesearch nucleussearch Cajal bodysearch chromosome, telomeric regionsearch centrosomesearch cytoskeletonsearch Y chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch microtubule organizing centersearch transcription factor complexsearch condensed chromosomesearch cytoplasmsearch cytosolsearch X chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch