DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN
The structure was published by Kontopidis, G., Mcinnes, C., Pandalaneni, S.R., et al., Wang, S., Walkinshaw, M.D., and Fischer, P.M., in 2006 in a paper entitled "Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2005.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN). The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 290 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: