2c5x Summary



The structure was published by Kontopidis, G., Mcinnes, C., Pandalaneni, S.R., et al., Wang, S., Walkinshaw, M.D., and Fischer, P.M., in 2006 in a paper entitled "Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
B CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 259 99%
D CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 259 99%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (174 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) ATP bindingsearch protein kinase activitysearch protein bindingsearch cyclin bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch kinase activitysearch metal ion bindingsearch histone kinase activitysearch transferase activitysearch nucleotide bindingsearch protein phosphorylationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch positive regulation of cell proliferationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch phosphorylationsearch blood coagulationsearch G1/S transition of mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch G2/M transition of mitotic cell cyclesearch DNA repairsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch histone phosphorylationsearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic nuclear divisionsearch centrosome duplicationsearch meiotic nuclear divisionsearch cell divisionsearch DNA replicationsearch cellular response to DNA damage stimulussearch regulation of gene silencingsearch cell cyclesearch mitotic G1 DNA damage checkpointsearch potassium ion transportsearch Ras protein signal transductionsearch mitotic cell cyclesearch cellular response to nitric oxidesearch nucleoplasmsearch nucleussearch cyclin-dependent protein kinase holoenzyme complexsearch centrosomesearch cytosolsearch cytoskeletonsearch condensed chromosomesearch cytoplasmsearch endosomesearch chromosome, telomeric regionsearch Cajal bodysearch microtubule organizing centersearch X chromosomesearch Y chromosomesearch transcription factor complexsearch
B, D (P20248) protein kinase bindingsearch regulation of cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch