2c5v Summary

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PDB entry 2c5v (supersedes 1oku)

DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN

The structure was published by Kontopidis, G., Mcinnes, C., Pandalaneni, S.R., et al., Wang, S., Walkinshaw, M.D., and Fischer, P.M., in 2006 in a paper entitled "Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, and ALA-ALA-ABA-ARG-SER-LEU-ILE-PFF-NH2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
B CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 259 99%
D CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 259 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (174 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch ATP bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch metal ion bindingsearch protein serine/threonine kinase activitysearch kinase activitysearch transferase activitysearch histone kinase activitysearch nucleotide bindingsearch protein phosphorylationsearch DNA repairsearch phosphorylationsearch G1/S transition of mitotic cell cyclesearch regulation of gene silencingsearch Ras protein signal transductionsearch cellular response to nitric oxidesearch mitotic cell cyclesearch cell divisionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch meiotic nuclear divisionsearch histone phosphorylationsearch DNA replicationsearch cell cyclesearch centrosome duplicationsearch G2/M transition of mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch mitotic nuclear divisionsearch positive regulation of cell proliferationsearch potassium ion transportsearch cellular response to DNA damage stimulussearch blood coagulationsearch positive regulation of DNA-dependent DNA replication initiationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch nucleoplasmsearch chromosome, telomeric regionsearch endosomesearch cytoplasmsearch Cajal bodysearch cyclin-dependent protein kinase holoenzyme complexsearch X chromosomesearch nucleussearch centrosomesearch cytosolsearch condensed chromosomesearch transcription factor complexsearch Y chromosomesearch microtubule organizing centersearch cytoskeletonsearch
B, D (P20248) protein kinase bindingsearch regulation of cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch