2c5v Summary


PDB entry 2c5v (supersedes 1oku)


The structure was published by Kontopidis, G., Mcinnes, C., Pandalaneni, S.R., et al., Wang, S., Walkinshaw, M.D., and Fischer, P.M., in 2006 in a paper entitled "Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, and ALA-ALA-ABA-ARG-SER-LEU-ILE-PFF-NH2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
B CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 259 99%
D CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 259 99%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (174 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P24941) meiotic nuclear divisionsearch DNA replicationsearch positive regulation of transcription, DNA-templatedsearch protein phosphorylationsearch mitotic G2 phasesearch potassium ion transportsearch mitotic G1 DNA damage checkpointsearch positive regulation of DNA-dependent DNA replication initiationsearch cellular response to DNA damage stimulussearch phosphorylationsearch histone phosphorylationsearch G2/M transition of mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch centrosome duplicationsearch regulation of gene silencingsearch G1/S transition of mitotic cell cyclesearch Ras protein signal transductionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cell divisionsearch positive regulation of cell proliferationsearch cellular response to nitric oxidesearch mitotic cell cyclesearch mitotic nuclear divisionsearch blood coagulationsearch cell cyclesearch DNA repairsearch protein bindingsearch transferase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch nucleotide bindingsearch metal ion bindingsearch histone kinase activitysearch cyclin bindingsearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch nucleoplasmsearch transcription factor complexsearch cytosolsearch nucleussearch cytoskeletonsearch endosomesearch cytoplasmsearch Cajal bodysearch chromosome, telomeric regionsearch X chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch condensed chromosomesearch centrosomesearch microtubule organizing centersearch Y chromosomesearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch