2c5v Summary


PDB entry 2c5v (supersedes 1oku)


The structure was published by Kontopidis, G., Mcinnes, C., Pandalaneni, S.R., et al., Wang, S., Walkinshaw, M.D., and Fischer, P.M., in 2006 in a paper entitled "Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, and ALA-ALA-ABA-ARG-SER-LEU-ILE-PFF-NH2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
B CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 259 99%
D CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 259 99%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (174 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch ATP bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch metal ion bindingsearch protein serine/threonine kinase activitysearch kinase activitysearch transferase activitysearch histone kinase activitysearch nucleotide bindingsearch protein phosphorylationsearch DNA repairsearch phosphorylationsearch G1/S transition of mitotic cell cyclesearch regulation of gene silencingsearch Ras protein signal transductionsearch cellular response to nitric oxidesearch mitotic cell cyclesearch cell divisionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch meiotic nuclear divisionsearch histone phosphorylationsearch DNA replicationsearch cell cyclesearch centrosome duplicationsearch G2/M transition of mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch mitotic nuclear divisionsearch positive regulation of cell proliferationsearch potassium ion transportsearch cellular response to DNA damage stimulussearch blood coagulationsearch positive regulation of DNA-dependent DNA replication initiationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch nucleoplasmsearch chromosome, telomeric regionsearch endosomesearch cytoplasmsearch Cajal bodysearch cyclin-dependent protein kinase holoenzyme complexsearch X chromosomesearch nucleussearch centrosomesearch cytosolsearch condensed chromosomesearch transcription factor complexsearch Y chromosomesearch microtubule organizing centersearch cytoskeletonsearch
B, D (P20248) protein kinase bindingsearch regulation of cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch