2c4l Summary

pdbe.org/2c4l
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STRUCTURE OF NEURAMINIDASE SUBTYPE N9 COMPLEXED WITH 30 MM SIALIC ACID (NANA, NEU5AC), CRYSTAL SOAKED FOR 24 HOURS AT 291 K AND FINALLY BACKSOAKED FOR 30 MIN IN A CRYOPROTECTANT SOLUTION WHICH DID NOT CONTAIN NEU5AC

A publication describing this structure is not available. The depositing authors are Rudino-Pinera, E.search; Tunnah, P.search; Crennell, S.J.search; Webster, R.G.search; Laver, W.G.search; Garman, E.F.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of NEURAMINIDASE SUBTYPE N9. This molecule has the UniProt identifier P03472 (NRAM_I75A5)search. The sample contained 388 residues which is < 90% of the natural sequence. Out of 388 residues 388 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A NEURAMINIDASE SUBTYPE N9 P03472 (83-470) (NRAM_I75A5)search Influenza A virus (A/tern/Australia/G70C/1975(H11N9))search < 90% 388 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03472 (83 - 470) NEURAMINIDASE SUBTYPE N9 Influenza A virus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Sialidases (neuraminidases)search Neuraminidasesearch Neuraminidasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P03472) virion membranesearch membranesearch host cell membranesearch carbohydrate metabolic processsearch exo-alpha-sialidase activitysearch

Chain InterPro annotation
A Glycoside hydrolase, family 34search Sialidasessearch