2c4g Summary

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STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514

The structure was published by Pevarello, P., Fancelli, D., Vulpetti, A., et al., Roletto, F., Varasi, M., and Brasca, M.G., in 2006 in a paper entitled "3-Amino-1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazoles: A New Class of Cdk2 Inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 99% 309 97%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 99% 309 97%
B CYCLIN A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 265 97%
D CYCLIN A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 265 97%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (173 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch histone kinase activitysearch transferase activitysearch nucleotide bindingsearch metal ion bindingsearch protein phosphorylationsearch Ras protein signal transductionsearch DNA repairsearch cell cyclesearch meiotic nuclear divisionsearch mitotic G1 DNA damage checkpointsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch DNA replicationsearch centrosome duplicationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch histone phosphorylationsearch positive regulation of cell proliferationsearch G2/M transition of mitotic cell cyclesearch regulation of gene silencingsearch G1/S transition of mitotic cell cyclesearch potassium ion transportsearch positive regulation of transcription, DNA-templatedsearch mitotic G2 phasesearch blood coagulationsearch cell divisionsearch mitotic nuclear divisionsearch cellular response to DNA damage stimulussearch cellular response to nitric oxidesearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch phosphorylationsearch nucleoplasmsearch cytosolsearch endosomesearch X chromosomesearch condensed chromosomesearch nucleussearch cytoplasmsearch Y chromosomesearch chromosome, telomeric regionsearch transcription factor complexsearch cytoskeletonsearch Cajal bodysearch cyclin-dependent protein kinase holoenzyme complexsearch microtubule organizing centersearch centrosomesearch
B, D (P20248) protein kinase bindingsearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of cell cyclesearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch