2c4g Summary



The structure was published by Pevarello, P., Fancelli, D., Vulpetti, A., et al., Roletto, F., Varasi, M., and Brasca, M.G., in 2006 in a paper entitled "3-Amino-1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazoles: A New Class of Cdk2 Inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 309 97%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 309 97%
B CYCLIN A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 265 97%
D CYCLIN A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 265 97%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (173 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P24941) protein phosphorylationsearch meiotic nuclear divisionsearch mitotic G1 DNA damage checkpointsearch cell cyclesearch Ras protein signal transductionsearch positive regulation of transcription, DNA-templatedsearch centrosome duplicationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch DNA repairsearch DNA replicationsearch positive regulation of DNA-dependent DNA replication initiationsearch cellular response to DNA damage stimulussearch G1/S transition of mitotic cell cyclesearch potassium ion transportsearch phosphorylationsearch regulation of gene silencingsearch cell divisionsearch G2/M transition of mitotic cell cyclesearch positive regulation of cell proliferationsearch histone phosphorylationsearch cellular response to nitric oxidesearch mitotic cell cyclesearch blood coagulationsearch mitotic nuclear divisionsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch protein kinase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch ATP bindingsearch kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch metal ion bindingsearch cyclin bindingsearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch histone kinase activitysearch transferase activitysearch nucleoplasmsearch microtubule organizing centersearch cytoskeletonsearch endosomesearch cytosolsearch cyclin-dependent protein kinase holoenzyme complexsearch Cajal bodysearch cytoplasmsearch chromosome, telomeric regionsearch nucleussearch Y chromosomesearch transcription factor complexsearch X chromosomesearch centrosomesearch condensed chromosomesearch
B, D (P20248) regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cell cyclesearch protein kinase bindingsearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch