› 2c47

X-ray diffraction
2.4Å resolution

Structure of casein kinase 1 gamma 2

Released:
DOI: 10.2210/pdb2c47/pdb
PDB entry 2c47 coloured by chain, front view.
PDB entry 2c47 coloured by chain, side view.
PDB entry 2c47 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bunkoczi G, Rellos P, Das S, Ugochukwu E, Fedorov O, Sobott F, Eswaran J, Amos A, Ball L, von Delft F, Bullock A, Debreczeni J, Turnbull A, Sundstrom M, Weigelt J, Arrowsmith C, Edwards A, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160258 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform gamma-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 313 amino acids
Theoretical weight: 36.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P78368 (Residues: 43-353; Coverage: 75%)
Gene names: CK1G2, CSNK1G2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 5ID 4 x 5ID
Ligand MG 2 x MG
1 modified residue:
Ligand CSD 4 x CSD

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 93.959Å b: 97.088Å c: 185.914Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.208 0.257
Expression system: Escherichia coli BL21(DE3)

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