2c3t Summary

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HUMAN GLUTATHIONE-S-TRANSFERASE T1-1, W234R MUTANT, APO FORM

The structure was published by Tars, K., Larsson, A.-K., Shokeer, A., Olin, B., Mannervik, B., and Kleywegt, G.J., in 2006 in a paper entitled "Structural Basis of the Suppressed Catalytic Activity of Wild-Type Human Glutathione Transferase T1-1 Compared to its W234R Mutant." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of GLUTATHIONE S-TRANSFERASE THETA 1.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLUTATHIONE S-TRANSFERASE THETA 1 P30711 (2-240) (GSTT1_HUMAN)search Homo sapienssearch 100% 247 96%
B GLUTATHIONE S-TRANSFERASE THETA 1 P30711 (2-240) (GSTT1_HUMAN)search Homo sapienssearch 100% 247 96%
C GLUTATHIONE S-TRANSFERASE THETA 1 P30711 (2-240) (GSTT1_HUMAN)search Homo sapienssearch 100% 247 96%
D GLUTATHIONE S-TRANSFERASE THETA 1 P30711 (2-240) (GSTT1_HUMAN)search Homo sapienssearch 100% 247 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P30711 (2 - 240) GLUTATHIONE S-TRANSFERASE THETA 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P30711) Glutaredoxinsearch, Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2search PF00043: Glutathione S-transferase, C-terminal domainsearch, PF02798: Glutathione S-transferase, N-terminal domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, D (P30711) oxidation-reduction processsearch glutathione metabolic processsearch glutathione derivative biosynthetic processsearch xenobiotic metabolic processsearch small molecule metabolic processsearch cytosolsearch cytoplasmsearch extracellular vesicular exosomesearch glutathione peroxidase activitysearch glutathione transferase activitysearch transferase activitysearch

Chain InterPro annotation
A, B, C, D Glutathione S-transferase, N-terminalsearch Glutathione S-transferase, C-terminalsearch Glutathione S-transferase, C-terminal-likesearch Thioredoxin-like foldsearch