IDENTIFICATION OF A BURIED POCKET FOR POTENT AND SELECTIVE INHIBITION OF CHK1: PREDICTION AND VERIFICATION
The structure was published by Foloppe, N., Fisher, L.M., Francis, G., Howes, R., Kierstan, P., and Potter, A., in 2006 in a paper entitled "Identification of a Buried Pocket for Potent and Selective Inhibition of Chk1: Prediction and Verification." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 2005.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of SERINE/THREONINE-PROTEIN KINASE CHK1. This molecule has the UniProt identifier O14757 (CHK1_HUMAN). The sample contained 297 residues which is < 90% of the natural sequence. Out of 297 residues 264 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: