2c3i Summary

pdbe.org/2c3i
spacer

CRYSTAL STRUCTURE OF HUMAN PIM1 IN COMPLEX WITH IMIDAZOPYRIDAZIN I

The structure was published by Pogacic, V., Bullock, A.N., Fedorov, O., et al., Meyer-Monard, S., Knapp, S., and Schwaller, J., in 2007 in a paper entitled "Structural Analysis Identifies Imidazo[1,2- B]Pyridazines as Pim Kinase Inhibitors with in Vitro Antileukemic Activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PIMTIDE and PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PIMTIDE Not available
HOMO SAPIENSsearch Not available 8 100%
B PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1 P11309 (92-404) (PIM1_HUMAN)search Homo sapienssearch < 90% 313 84%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11309 (92 - 404) PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A
B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
B (P11309) protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A
B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch