› 2c3b

X-ray diffraction
1.85Å resolution

The Crystal Structure of Aspergillus fumigatus Cyclophilin reveals 3D Domain Swapping of a Central Element

Released:
DOI: 10.2210/pdb2c3b/pdb
PDB entry 2c3b coloured by chain, front view.
PDB entry 2c3b coloured by chain, side view.
PDB entry 2c3b coloured by chain, top view.
Source organism: Aspergillus fumigatus
Primary publication:
The crystal structure of Aspergillus fumigatus cyclophilin reveals 3D domain swapping of a central element.
Limacher A, Kloer DP, Flückiger S, Folkers G, Crameri R, Scapozza L
Structure 14 185-95 (2006)
PMID: 16472738

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175823 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 172 amino acids
Theoretical weight: 18.9 KDa
Source organism: Aspergillus fumigatus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4WHY9 (Residues: 1-205; Coverage: 83%)
Gene name: AFUA_2G03720
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3121
Unit cell:
a: 64.829Å b: 64.829Å c: 156.288Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.189 0.214
Expression system: Escherichia coli

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Citations

11 review citations

The spectrum of fungal allergy.
Simon-Nobbe et al. (2008)
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5 mentions without citation

Structure of allergens and structure based epitope predictions.
Dall'antonia et al. (2014)
4 more