2c3b Summary

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THE CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CYCLOPHILIN REVEALS 3D DOMAIN SWAPPING OF A CENTRAL ELEMENT

The structure was published by Limacher, A., Kloer, D.P., Fluckiger, S., Folkers, G., Crameri, R., and Scapozza, L., in 2006 in a paper entitled "The Crystal Structure of Aspergillus Fumigatus Cyclophilin Reveals 3D Domain Swapping of a Central Element" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PPIASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PPIASE Q4WHY9 (1-205) (Q4WHY9_ASPFU)search Aspergillus fumigatus Af293search < 90% 172 81%
B PPIASE Q4WHY9 (1-205) (Q4WHY9_ASPFU)search Aspergillus fumigatus Af293search < 90% 172 81%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q4WHY9 (1 - 205) PPIASE Aspergillus fumigatus

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B Cyclophilin (peptidylprolyl isomerase)search Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLDsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q4WHY9) peptidyl-prolyl cis-trans isomerase activitysearch protein foldingsearch protein peptidyl-prolyl isomerizationsearch

Chain InterPro annotation
A, B Cyclophilin-type peptidyl-prolyl cis-trans isomerase domainsearch Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved sitesearch Cyclophilin-type peptidyl-prolyl cis-trans isomerasesearch Cyclophilin-like domainsearch