Function and Biology

THE CRYSTAL STRUCTURE OF A CYS25ALA MUTANT OF HUMAN PROCATHEPSIN S

Source organism: Homo sapiens
Biochemical function: proteoglycan binding
Biological process: positive regulation of cation channel activity
Cellular component: ficolin-1-rich granule lumen

EC 3.4.22.27: Cathepsin S

Reaction catalysed:
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|- compound.

Sequence families

Pfam Protein families (Pfam)
PF00112
Domain description: Papain family cysteine protease
Occurring in:
  1. Cathepsin S
The deposited structure of PDB entry 2c0y contains 1 copy of Pfam domain PF00112 (Papain family cysteine protease) in Cathepsin S. Showing 1 copy in chain A.

PF08246
Domain description: Cathepsin propeptide inhibitor domain (I29)
Occurring in:
  1. Cathepsin S
The deposited structure of PDB entry 2c0y contains 1 copy of Pfam domain PF08246 (Cathepsin propeptide inhibitor domain (I29)) in Cathepsin S. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000668
Domain description: Peptidase C1A, papain C-terminal
Occurring in:
  1. Cathepsin S
IPR013201
Domain description: Cathepsin propeptide inhibitor domain (I29)
Occurring in:
  1. Cathepsin S
IPR025661
Domain description: Cysteine peptidase, asparagine active site
Occurring in:
  1. Cathepsin S
IPR025660
Domain description: Cysteine peptidase, histidine active site
Occurring in:
  1. Cathepsin S
IPR039417
Domain description: Papain-like cysteine endopeptidase
Occurring in:
  1. Cathepsin S
IPR013128
Domain description: Peptidase C1A
Occurring in:
  1. Cathepsin S
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Cathepsin S

Structure domain

CATH CATH domain
3.90.70.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Cathepsin B; Chain A
Homology: Cysteine proteinases
Occurring in:
  1. Cathepsin S
The deposited structure of PDB entry 2c0y contains 1 copy of CATH domain 3.90.70.10 (Cathepsin B; Chain A) in Cathepsin S. Showing 1 copy in chain A.