2c0t Summary



The structure was published by Burchat, A., Borhani, D.W., Calderwood, D.J., Hirst, G.C., Li, B., and Stachlewitz, R.F., in 2006 in a paper entitled "Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of TYROSINE-PROTEIN KINASE HCK.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TYROSINE-PROTEIN KINASE HCK P08631 (81-526) (HCK_HUMAN)search Homo sapienssearch < 90% 454 94%
B TYROSINE-PROTEIN KINASE HCK P08631 (81-526) (HCK_HUMAN)search Homo sapienssearch < 90% 454 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08631 (81 - 526) TYROSINE-PROTEIN KINASE HCK Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B SH3 Domainssearch, SHC Adaptor Proteinsearch, Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search SH2 domainsearch, SH3 domainsearch, Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P08631) protein kinase activitysearch protein tyrosine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch SH2 domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch SH3 domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch