2bzk Summary

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CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH AMPPNP AND PIMTIDE

A publication describing this structure is not available. The depositing authors are Debreczeni, J.E.search; Bullock, A.search; Knapp, S.search; Von Delft, F.search; Sundstrom, M.search; Arrowsmith, C.search; Weigelt, J.search; Edwards, A.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.45 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PIMTIDE and PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PIMTIDE Not available
HOMO SAPIENSsearch Not available 15 46%
B PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1 P11309 (92-404) (PIM1_HUMAN)search Homo sapienssearch < 90% 313 85%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11309 (92 - 404) PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A
B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
B (P11309) ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A
B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch