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CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH AMPPNP AND PIMTIDE

X-ray diffraction
2.45Å resolution
PDB entry 2bzk coloured by chain, front view.
PDB entry 2bzk coloured by chain, side view.
PDB entry 2bzk coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase pim-1 and peptide
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Multimeric state: hetero dimer
Accessible surface area: 13048.53 Å2
Buried surface area: 1780.14 Å2
Dissociation area: 493.82 Å2
Dissociation energy (ΔGdiss): -2.73 kcal/mol
Dissociation entropy (TΔSdiss): 6.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145755

Macromolecules

PIMTIDE
Chain: A
Length: 15 amino acids
Theoretical weight: 1.59 KDa
Source organism: Homo sapiens
Expression system: Not provided
PIMTIDE in PDB entry 2bzk, assembly 1, front view.
PIMTIDE in PDB entry 2bzk, assembly 1, side view.
PIMTIDE in PDB entry 2bzk, assembly 1, top view.
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Serine/threonine-protein kinase pim-1
Chain: B
Length: 313 amino acids
Theoretical weight: 35.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P11309 (Residues: 1-313; Coverage: 100%)
Gene name: PIM1
Pfam: Protein kinase domain
InterPro:
CATH:
Serine/threonine-protein kinase pim-1 in PDB entry 2bzk, assembly 1, front view.
Serine/threonine-protein kinase pim-1 in PDB entry 2bzk, assembly 1, side view.
Serine/threonine-protein kinase pim-1 in PDB entry 2bzk, assembly 1, top view.
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