2buj Summary

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CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16 IN COMPLEX WITH STAUROSPORINE

A publication describing this structure is not available. The depositing authors are Debreczeni, J.E.search; Eswaran, J.search; Bullock, A.search; Filippakopoulos, P.search; Kavanagh, K.search; Amos, A.search; Fedorov, O.search; Sobott, F.search; Ball, L.J.search; Von Delft, F.search; Arrowsmith, C.search; Sundstrom, M.search; Edwards, A.search; Knapp, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of SERINE/THREONINE-PROTEIN KINASE 16.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SERINE/THREONINE-PROTEIN KINASE 16 O75716 (13-305) (STK16_HUMAN)search Homo sapienssearch 96% 317 91%
B SERINE/THREONINE-PROTEIN KINASE 16 O75716 (13-305) (STK16_HUMAN)search Homo sapienssearch 96% 317 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O75716 (13 - 305) SERINE/THREONINE-PROTEIN KINASE 16 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (O75716) Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (O75716) protein phosphorylationsearch protein autophosphorylationsearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to transforming growth factor beta stimulussearch phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch nucleotide bindingsearch transferase activitysearch protein bindingsearch non-membrane spanning protein tyrosine kinase activitysearch kinase activitysearch RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionsearch Golgi-associated vesiclesearch perinuclear region of cytoplasmsearch membranesearch cytoplasmsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch