2btr Summary



The structure was published by Vulpetti, A., Casale, E., Roletto, F., Amici, R., Villa, M., and Pevarello, P., in 2006 in a paper entitled "Structure-Based Drug Design to the Discovery of New 2-Aminothiazole Cdk2 Inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 274 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch metal ion bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activitysearch nucleotide bindingsearch histone kinase activitysearch protein phosphorylationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch potassium ion transportsearch Ras protein signal transductionsearch phosphorylationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch centrosome duplicationsearch DNA replicationsearch G2/M transition of mitotic cell cyclesearch blood coagulationsearch positive regulation of DNA-dependent DNA replication initiationsearch cellular response to nitric oxidesearch positive regulation of cell proliferationsearch G1/S transition of mitotic cell cyclesearch cell cyclesearch mitotic cell cyclesearch mitotic nuclear divisionsearch positive regulation of transcription, DNA-templatedsearch histone phosphorylationsearch meiotic nuclear divisionsearch mitotic G1 DNA damage checkpointsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cellular response to DNA damage stimulussearch cell divisionsearch DNA repairsearch regulation of gene silencingsearch nucleoplasmsearch condensed chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch cytoplasmsearch transcription factor complexsearch nucleussearch cytosolsearch Cajal bodysearch microtubule organizing centersearch endosomesearch X chromosomesearch Y chromosomesearch chromosome, telomeric regionsearch centrosomesearch cytoskeletonsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch