2btp Summary

pdbe.org/2btp
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14-3-3 PROTEIN THETA (HUMAN) COMPLEXED TO PEPTIDE

The structure was published by Yang, X., Lee, W.H., Sobott, F., et al., Sundstrom, M., Doyle, D.A., and Elkins, J.M., in 2006 in a paper entitled "Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely 14-3-3 PROTEIN TAU and CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 14-3-3 PROTEIN TAU P27348 (1-234) (1433T_HUMAN)search Homo sapienssearch 96% 256 96%
B 14-3-3 PROTEIN TAU P27348 (1-234) (1433T_HUMAN)search Homo sapienssearch 96% 256 96%
P CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS Not available
HOMO SAPIENSsearch Not available 6 100%
Q CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS Not available
HOMO SAPIENSsearch Not available 6 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P27348 (1 - 234) 14-3-3 PROTEIN TAU Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P27348) Delta-Endotoxin; domain 1search PF00244: 14-3-3 proteinsearch
P, Q

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P27348) apoptotic processsearch substantia nigra developmentsearch membrane organizationsearch positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwaysearch protein targetingsearch negative regulation of transcription, DNA-templatedsearch intrinsic apoptotic signaling pathwaysearch small GTPase mediated signal transductionsearch protein bindingsearch 14-3-3 protein bindingsearch protein domain specific bindingsearch protein N-terminus bindingsearch extracellular vesicular exosomesearch cytoplasmsearch membranesearch protein complexsearch cytoplasmic vesicle membranesearch cytosolsearch focal adhesionsearch

Chain InterPro annotation
A, B 14-3-3 proteinsearch 14-3-3 protein, conserved sitesearch 14-3-3 domainsearch
P, Q