2btp Summary

pdbe.org/2btp
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14-3-3 PROTEIN THETA (HUMAN) COMPLEXED TO PEPTIDE

The structure was published by Yang, X., Lee, W.H., Sobott, F., et al., Sundstrom, M., Doyle, D.A., and Elkins, J.M., in 2006 in a paper entitled "Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely 14-3-3 PROTEIN TAU and CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 14-3-3 PROTEIN TAU P27348 (1-234) (1433T_HUMAN)search Homo sapienssearch 96% 256 96%
B 14-3-3 PROTEIN TAU P27348 (1-234) (1433T_HUMAN)search Homo sapienssearch 96% 256 96%
P CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS Not available
HOMO SAPIENSsearch Not available 6 100%
Q CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS Not available
HOMO SAPIENSsearch Not available 6 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P27348 (1 - 234) 14-3-3 PROTEIN TAU Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P27348) Delta-Endotoxin; domain 1search PF00244: 14-3-3 proteinsearch
P, Q

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P27348) protein bindingsearch protein domain specific bindingsearch protein N-terminus bindingsearch cytoplasmsearch cytosolsearch focal adhesionsearch membranesearch cytoplasmic vesicle membranesearch protein complexsearch extracellular vesicular exosomesearch protein targetingsearch apoptotic processsearch small GTPase mediated signal transductionsearch substantia nigra developmentsearch negative regulation of transcription, DNA-templatedsearch membrane organizationsearch intrinsic apoptotic signaling pathwaysearch positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwaysearch

Chain InterPro annotation
A, B 14-3-3 proteinsearch 14-3-3 protein, conserved sitesearch 14-3-3 domainsearch
P, Q