2bsx Summary

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CRYSTAL STRUCTURE OF THE PLASMODIUM FALCIPARUM PURINE NUCLEOSIDE PHOSPHORYLASE COMPLEXED WITH INOSINE

The structure was published by Schnick, C., Robien, M.A., Brzozowski, A.M., et al., Hol, W.G.J., Brannigan, J.A., and Wilkinson, A.J., in 2005 in a paper entitled "Structures of Plasmodium Falciparum Purine Nucleoside Phosphorylase Complexed with Sulfate and its Natural Substrate Inosine" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of PURINE NUCLEOSIDE PHOSPHORYLASE. This molecule has the UniProt identifier Q8I3X4 (Q8I3X4_PLAF7)search. The sample contained 253 residues which is 100% of the natural sequence. Out of 253 residues 241 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PURINE NUCLEOSIDE PHOSPHORYLASE Q8I3X4 (1-245) (Q8I3X4_PLAF7)search Plasmodium falciparum 3D7search 100% 253 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q8I3X4 (1 - 245) PURINE NUCLEOSIDE PHOSPHORYLASE Plasmodium falciparum 3D7

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q8I3X4) Purine and uridine phosphorylasessearch Rossmann foldsearch PF01048: Phosphorylase superfamilysearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q8I3X4) transferase activitysearch transferase activity, transferring glycosyl groupssearch catalytic activitysearch metal ion bindingsearch uridine phosphorylase activitysearch nucleoside metabolic processsearch

Chain InterPro annotation
A Nucleoside phosphorylase domainsearch Nucleoside phosphorylasesearch