› 2bqq

X-ray diffraction
2.2Å resolution

X-ray Structure of the N-terminal Domain of Human Doublecortin

Released:
DOI: 10.2210/pdb2bqq/pdb
PDB entry 2bqq coloured by chain, front view.
PDB entry 2bqq coloured by chain, side view.
PDB entry 2bqq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The DC-module of doublecortin: dynamics, domain boundaries, and functional implications.
Cierpicki T, Kim MH, Cooper DR, Derewenda U, Bushweller JH, Derewenda ZS
Proteins 64 874-82 (2006)
PMID: 16835924

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129021 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuronal migration protein doublecortin Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43602 (Residues: 45-150; Coverage: 29%)
Gene names: DBCN, DCX, LISX
Sequence domains: Doublecortin
Structure domains: Doublecortin domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: I422
Unit cell:
a: 61.655Å b: 61.655Å c: 116.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.173 0.237
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Role of cytoskeletal abnormalities in the neuropathology and pathophysiology of type I lissencephaly.
Friocourt et al. (2011)
1 more

5 mentions without citation

Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis.
Carli et al. (2023)
4 more