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EBI PDBe PDBeView

PDBe Entry: 2blb view

X-RAY CRYSTAL STRUCTURE OF PLASMODIUM VIVAX DIHYDROFOLATE REDUCTASE IN COMPLEX WITH PYRIMETHAMINE AND ITS DERIVATIVE
Summary
Header OXIDOREDUCTASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 3.0 Å, R-factor: 19.2%, Free R-factor: 30.0%, Spacegroup: C 1 2 1
Released 07/09/2005, deposition: 03/03/2005, last revision: 24/02/2009
Authors Kongsaeree, P.search; Khongsuk, P.search; Leartsakulpanich, U.search; Chitnumsub, P.search; Tarnchompoo, B.search; Walkinshaw, M.D.search; Yuthavong, Y.search
Primary citation Crystal Structure of Dihydrofolate Reductase from Plasmodium Vivax: Pyrimethamine Displacement Linked with Mutation-Induced Resistance.
PROC.NATL.ACAD.SCI.USAsearch vol:102, pag:13046 (2005) [PubMed ID 16135570 ]search
Keywords DIHYDROFOLATE REDUCTASEsearch, PLAMODIUM VIVAXsearch, PYRIMETHAMINEsearch, MALARIAsearch, DRUG RESISTANCEsearch, OXIDOREDUCTASEsearch
EC 1.5.1.3 ExPASy BRENDA search 2.1.1.45 ExPASy BRENDA search (A)
Organism Plasmodium vivax(malaria parasite P. vivax) 5855search(A)
UniProt Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] O02604search (A)
Solvent A
Related entries 2bl9, 2bla, 2blc
Polymers
Id Name Type UniProt Residues Observed
A DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE Protein O02604 (DRTS_PLAVI)search
 238 91%
Heterogens
Id Name Ligands
A NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE NDP search
A 6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE CP7 search
A 2-(N-MORPHOLINO)-ETHANESULFONIC ACID MES search
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