2bkh Summary

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MYOSIN VI NUCLEOTIDE-FREE (MDINSERT2) CRYSTAL STRUCTURE

The structure was published by Menetrey, J., Bahloul, A., Wells, A., et al., Morris, C., Sweeney, H.L., and Houdusse, A., in 2005 in a paper entitled "The Structure of the Myosin Vi Motor Reveals the Mechanism of Directionality Reversal" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely UNCONVENTIONAL MYOSIN and CALMODULIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A UNCONVENTIONAL MYOSIN Q29122 (2-816) (MYO6_PIG)search Sus scrofasearch < 90% 814 96%
B CALMODULIN P62152 (2-148) (CALM_DROME)search Drosophila melanogastersearch 99% 149 91%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q29122 (2 - 816) UNCONVENTIONAL MYOSIN Sus scrofa
P62152 (2 - 148) CALMODULIN Drosophila melanogaster

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Myosin head (motor domain)search
B (P62152) Calmodulin-likesearch EF-handsearch PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (Q29122) myosin complexsearch motor activitysearch ATP bindingsearch
B (P62152) centriolesearch myosin VI complexsearch rhabdomeresearch microtubule associated complexsearch spindle polesearch spindlesearch cytoplasmsearch midbodysearch myosin V complexsearch calcium ion bindingsearch protein bindingsearch myosin VI head/neck bindingsearch myosin V bindingsearch myosin heavy chain bindingsearch metal ion bindingsearch calmodulin bindingsearch regulation of light-activated channel activitysearch rhodopsin mediated signaling pathwaysearch actin filament-based movementsearch deactivation of rhodopsin mediated signalingsearch mitotic spindle organizationsearch centriole replicationsearch photoreceptor cell axon guidancesearch adaptation of rhodopsin mediated signalingsearch metarhodopsin inactivationsearch positive regulation of NFAT protein import into nucleussearch lateral inhibitionsearch protein phosphorylationsearch sensory perception of soundsearch regulation of response to DNA damage stimulussearch kinetochore organizationsearch muscle cell cellular homeostasissearch rhabdomere developmentsearch

Chain InterPro annotation
A Myosin head, motor domainsearch P-loop containing nucleoside triphosphate hydrolasesearch
B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch