2bhh Summary

pdbe.org/2bhh
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HUMAN CYCLIN DEPENDENT PROTEIN KINASE 2 IN COMPLEX WITH THE INHIBITOR 4-HYDROXYPIPERINDINESULFONYL-INDIRUBINE

The structure was published by Schaefer, M., Jautelat, R., Brumby, T., et al., Luecking, U., Prien, O., and Siemeister, G., in 2005 in a paper entitled "From the Insoluble Dye Indirubin Towards Highly Active, Soluble Cdk2-Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 274 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P24941) protein phosphorylationsearch blood coagulationsearch regulation of gene silencingsearch positive regulation of DNA-dependent DNA replication initiationsearch DNA replicationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch potassium ion transportsearch phosphorylationsearch DNA repairsearch cell divisionsearch G2/M transition of mitotic cell cyclesearch G1/S transition of mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch mitotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch meiotic nuclear divisionsearch positive regulation of transcription, DNA-templatedsearch histone phosphorylationsearch cellular response to DNA damage stimulussearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cellular response to nitric oxidesearch mitotic nuclear divisionsearch cell cyclesearch centrosome duplicationsearch positive regulation of cell proliferationsearch Ras protein signal transductionsearch protein serine/threonine kinase activitysearch protein kinase activitysearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch transferase activitysearch kinase activitysearch cyclin bindingsearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch metal ion bindingsearch histone kinase activitysearch nucleoplasmsearch cytoplasmsearch cytoskeletonsearch nucleussearch microtubule organizing centersearch chromosome, telomeric regionsearch condensed chromosomesearch cytosolsearch endosomesearch X chromosomesearch transcription factor complexsearch Y chromosomesearch Cajal bodysearch centrosomesearch cyclin-dependent protein kinase holoenzyme complexsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch