2bhg Summary

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3C PROTEASE FROM TYPE A10(61) FOOT-AND-MOUTH DISEASE VIRUS

The structure was published by Birtley, J.R., Knox, S.R., Jaulent, A.M., Brick, P., Leatherbarrow, R.J., and Curry, S., in 2005 in a paper entitled "Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease: New Insights Into Catalytic Mechanism and Cleavage Specificity" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of FOOT-AND-MOUTH DISEASE VIRUS 3C PROTEASE.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FOOT-AND-MOUTH DISEASE VIRUS 3C PROTEASE P03306 (1650-1855) (POLG_FMDV1)search Foot-and-mouth disease virus (strain A10-61)search < 90% 209 92%
B FOOT-AND-MOUTH DISEASE VIRUS 3C PROTEASE P03306 (1650-1855) (POLG_FMDV1)search Foot-and-mouth disease virus (strain A10-61)search < 90% 209 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03306 (1650 - 1855) FOOT-AND-MOUTH DISEASE VIRUS 3C PROTEASE Foot-and-mouth disease virus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Viral cysteine protease of trypsin foldsearch Trypsin-like serine proteasessearch 3C cysteine protease (picornain 3C)search

Chain ID Molecular function (GO) Biological process (GO)
A, B (P03306) cysteine-type endopeptidase activitysearch catalytic activitysearch proteolysissearch

Chain InterPro annotation
A, B Peptidase C3A/C3B, picornaviralsearch Trypsin-like cysteine/serine peptidase domainsearch