2bfx Summary


Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin.

The structure was published by Sessa, F., Mapelli, M., Ciferri, C., et al., Schneider, T.R., Stukenberg, P.T., and Musacchio, A., in 2005 in a paper entitled "Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely AURORA KINASE B-A and INNER CENTROMERE PROTEIN A.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A AURORA KINASE B-A Q6DE08 (78-361) (AUKBA_XENLA)search Xenopus laevissearch < 90% 284 97%
B AURORA KINASE B-A Q6DE08 (78-361) (AUKBA_XENLA)search Xenopus laevissearch < 90% 284 97%
C INNER CENTROMERE PROTEIN A O13024 (798-840) (INCEA_XENLA)search Xenopus laevissearch < 90% 43 100%
D INNER CENTROMERE PROTEIN A O13024 (798-840) (INCEA_XENLA)search Xenopus laevissearch < 90% 43 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q6DE08 (78 - 361) AURORA KINASE B-A Xenopus laevis
O13024 (798 - 840) INNER CENTROMERE PROTEIN A Xenopus laevis

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch
C, D Inner centromere protein, ARK binding regionsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q6DE08) protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch mitotic nuclear divisionsearch protein phosphorylationsearch positive regulation of cytokinesissearch histone H3-S28 phosphorylationsearch spindle checkpointsearch chromosome passenger complexsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Aurora kinase Bsearch
C, D Inner centromere protein, ARK-binding domainsearch