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PDBe Entry: 2bev 
REACTIVITY MODULATION OF HUMAN BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE BY AN INTERNAL MOLECULAR SWITCH
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OXIDOREDUCTASE
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X-RAY DIFFRACTION
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Resolution: 1.8 Å, R-factor: 13.9%, Free R-factor: 17.0%, Spacegroup: P 31 2 1
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16/02/2006, deposition: 30/11/2004, last revision: 24/02/2009
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Machius, M.; Wynn, R.M.; Chuang, J.L.; Tomchick, D.R.; Brautigam, C.A.; Chuang, D.T.
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A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase.
STRUCTURE vol:14, pag:287 (2006) [PubMed ID 16472748 ]
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OXIDOREDUCTASE, KETOACID DEHYDROGENASE, BRANCHED-CHAIN, MULTI- ENZYME COMPLEX, ACYLATION, OXIDATIVE DECARBOXYLATION, MAPLE SYRUP URINE DISEASE, THIAMINE DIPHOSPHATE, PHOSPHORYLATION, CONFORMATIONAL SWITCH, REACTIVITY
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1.2.4.4 ExPASy BRENDA (A B)
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Homo sapiens(human) 9606(A B)
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2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDH E1-alpha) (BCKDE1A) P12694 (A)
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDH E1-beta) P21953 (B)
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A, B, C
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1dtw, 1ols, 1olu, 1olx, 1u5b, 1v11, 1v16, 1v1m, 1v1r, 1wci, 1x7w, 1x7x, 1x7y, 1x7z, 1x80, 2beu, 2bew, 2bfb, 2bfc, 2bfd, 2bfe, 2bff
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| A |
2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT |
Protein |
P12694 (ODBA_HUMAN)
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400 |
97% |
| B |
2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT |
Protein |
P21953 (ODBB_HUMAN)
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342 |
98% |
| C |
PEPTIDE ALA-TYR-ARG |
Protein |
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3 |
100% |
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| A |
C2-1-HYDROXY-2-METHYL-BUTYL-THIAMIN DIPHOSPHATE |
THY
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| A, B |
POTASSIUM ION |
K
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| A |
MANGANESE (II) ION |
MN
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| A, B |
CHLORIDE ION |
CL
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| B |
GLYCEROL |
GOL
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