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3D Structure of Alzheimer's Abeta(1-42) fibrils

Solution NMR
PDB entry 2beg coloured by chain, ensemble of 10 models, front view.
PDB entry 2beg coloured by chain, ensemble of 10 models, side view.
PDB entry 2beg coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Assembly composition:
homo pentamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Soluble APP-beta
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Multimeric state: homo pentamer
Accessible surface area: 6553.27 Å2
Buried surface area: 9438.09 Å2
Dissociation area: 4,719.04 Å2
Dissociation energy (ΔGdiss): 60.2 kcal/mol
Dissociation entropy (TΔSdiss): 36.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138401

Macromolecules

Amyloid-beta protein 42
Chains: A, B, C, D, E
Length: 42 amino acids
Theoretical weight: 4.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05067 (Residues: 672-713; Coverage: 6%)
Gene names: A4, AD1, APP
Pfam: Beta-amyloid peptide (beta-APP)
InterPro:
Amyloid-beta protein 42 in PDB entry 2beg, assembly 1, front view.
Amyloid-beta protein 42 in PDB entry 2beg, assembly 1, side view.
Amyloid-beta protein 42 in PDB entry 2beg, assembly 1, top view.
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