2bdj Summary

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Src kinase in complex with inhibitor AP23464

The structure was published by Dalgarno, D., Stehle, T., Narula, S., et al., Bohacek, R., Weigele, M., and Sawyer, T., in 2006 in a paper entitled "Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Proto-oncogene tyrosine-protein kinase Src. This molecule has the UniProt identifier P12931 (SRC_HUMAN)search. The sample contained 279 residues which is < 90% of the natural sequence. Out of 279 residues 254 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase Src P12931 (258-536) (SRC_HUMAN)search Homo sapienssearch 100% 279 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P12931 (258 - 536) Proto-oncogene tyrosine-protein kinase Src Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P12931) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF07714: Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P12931) protein phosphorylationsearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch