2baq Summary


p38alpha bound to Ro3201195

The structure was published by Sullivan, J.E., Holdgate, G.A., Campbell, D., et al., Read, J., Vanscyoc, W.S., and Ward, W.H., in 2005 in a paper entitled "Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 365 residues which is 100% of the natural sequence. Out of 365 residues 330 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 365 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q16539) protein bindingsearch transferase activitysearch protein kinase activitysearch MAP kinase activitysearch nucleotide bindingsearch ATP bindingsearch kinase activitysearch NFAT protein bindingsearch protein serine/threonine kinase activitysearch MAP kinase kinase activitysearch nucleoplasmsearch cytosolsearch cytoplasmsearch cellsearch nucleussearch extracellular vesicular exosomesearch mitochondrionsearch spindle polesearch cellular response to vascular endothelial growth factor stimulussearch osteoclast differentiationsearch toll-like receptor 3 signaling pathwaysearch platelet activationsearch cell surface receptor signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch peptidyl-serine phosphorylationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch positive regulation of myoblast differentiationsearch angiogenesissearch chemotaxissearch toll-like receptor 9 signaling pathwaysearch cellular response to DNA damage stimulussearch signal transduction in response to DNA damagesearch MyD88-independent toll-like receptor signaling pathwaysearch response to stresssearch regulation of transcription from RNA polymerase II promotersearch Ras protein signal transductionsearch toll-like receptor 10 signaling pathwaysearch MAPK cascadesearch positive regulation of myotube differentiationsearch striated muscle cell differentiationsearch lipopolysaccharide-mediated signaling pathwaysearch cellular response to ionizing radiationsearch positive regulation of blood vessel endothelial cell migrationsearch stress-induced premature senescencesearch toll-like receptor signaling pathwaysearch regulation of transcription, DNA-templatedsearch cell morphogenesissearch neurotrophin TRK receptor signaling pathwaysearch skeletal muscle tissue developmentsearch regulation of sequence-specific DNA binding transcription factor activitysearch response to lipopolysaccharidesearch p38MAPK cascadesearch apoptotic processsearch phosphorylationsearch innate immune responsesearch toll-like receptor 5 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch mRNA metabolic processsearch response to muramyl dipeptidesearch signal transductionsearch cartilage condensationsearch vascular endothelial growth factor receptor signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch intracellular signal transductionsearch chondrocyte differentiationsearch fatty acid oxidationsearch RNA metabolic processsearch glucose metabolic processsearch protein phosphorylationsearch blood coagulationsearch cellular response to lipopolysaccharidesearch negative regulation of canonical Wnt signaling pathwaysearch gene expressionsearch toll-like receptor 2 signaling pathwaysearch activation of MAPK activitysearch TRIF-dependent toll-like receptor signaling pathwaysearch DNA damage checkpointsearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of transcription from RNA polymerase II promotersearch cellular component movementsearch muscle cell differentiationsearch transcription, DNA-templatedsearch positive regulation of protein import into nucleussearch positive regulation of muscle cell differentiationsearch positive regulation of myoblast fusionsearch stress-activated MAPK cascadesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch