2b9i Summary


Crystal structure of Fus3 with a docking motif from Msg5

The structure was published by Remenyi, A., Good, M.C., Bhattacharyya, R.P., and Lim, W.A., in 2005 in a paper entitled "The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Mitogen-activated protein kinase FUS3 and Tyrosine-protein phosphatase MSG5.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase FUS3 P16892 (1-353) (FUS3_YEAST)search Saccharomyces cerevisiae S288csearch 100% 353 95%
C Tyrosine-protein phosphatase MSG5 Not available
Synthetic Not available 21 66%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P16892 (1 - 353) Mitogen-activated protein kinase FUS3 Saccharomyces cerevisiae

Chain Structural classification (CATH) Sequence family (Pfam)
A (P16892) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P16892) protein phosphorylationsearch MAPK cascadesearch cell cyclesearch invasive growth in response to glucose limitationsearch phosphorylationsearch negative regulation of MAPK cascadesearch cell divisionsearch positive regulation of protein export from nucleussearch mitotic nuclear divisionsearch pheromone-dependent signal transduction involved in conjugation with cellular fusionsearch cell cycle arrestsearch conjugationsearch negative regulation of transposition, RNA-mediatedsearch protein bindingsearch MAP kinase activitysearch transferase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch nucleotide bindingsearch identical protein bindingsearch kinase activitysearch periplasmic spacesearch mating projection tipsearch cytoplasmsearch nucleussearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch