2b8w Summary

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Crystal-structure of the N-terminal Large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with GMP/AlF4

The structure was published by Ghosh, A., Praefcke, G.J., Renault, L., Wittinghofer, A., and Herrmann, C., in 2006 in a paper entitled "How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.22 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Interferon-induced guanylate-binding protein 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Interferon-induced guanylate-binding protein 1 P32455 (1-317) (GBP1_HUMAN)search Homo sapienssearch 100% 328 88%
B Interferon-induced guanylate-binding protein 1 P32455 (1-317) (GBP1_HUMAN)search Homo sapienssearch 100% 328 88%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P32455 (1 - 317) Interferon-induced guanylate-binding protein 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P32455) P-loop containing nucleotide triphosphate hydrolasessearch PF02263: Guanylate-binding protein, N-terminal domainsearch, PF02841: Guanylate-binding protein, C-terminal domainsearch

Chain ID Molecular function (GO)
A, B (P32455) GTP bindingsearch GTPase activitysearch

Chain InterPro annotation
A, B Guanylate-binding protein, C-terminalsearch Guanylate-binding protein, N-terminalsearch P-loop containing nucleoside triphosphate hydrolasesearch