2b7a Summary

pdbe.org/2b7a
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The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

The structure was published by Lucet, I.S., Fantino, E., Styles, M., et al., Treutlein, H., Wilks, A.F., and Rossjohn, J., in 2006 in a paper entitled "The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Tyrosine-protein kinase JAK2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase JAK2 O60674 (840-1132) (JAK2_HUMAN)search Homo sapienssearch < 90% 293 98%
B Tyrosine-protein kinase JAK2 O60674 (840-1132) (JAK2_HUMAN)search Homo sapienssearch < 90% 293 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O60674 (840 - 1132) Tyrosine-protein kinase JAK2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (O60674) transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch