The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
The structure was published by Lucet, I.S., Fantino, E., Styles, M., et al., Treutlein, H., Wilks, A.F., and Rossjohn, J., in 2006 in a paper entitled "The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2005.
The experimental data on which the structure is based was not deposited.
This PDB entry contains multiple copies of the structure of Tyrosine-protein kinase JAK2.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: