› › Structure analysis

The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

X-ray diffraction
2Å resolution
PDB entry 2b7a coloured by chain, front view.
PDB entry 2b7a coloured by chain, side view.
PDB entry 2b7a coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Tyrosine-protein kinase JAK2
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 14166.09 Å2
Buried surface area: 714.0 Å2
Dissociation area: 357 Å2
Dissociation energy (ΔGdiss): -2.03 kcal/mol
Dissociation entropy (TΔSdiss): 4.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130063
Assembly 2
Download    3D Visualisation
Assembly Name: Tyrosine-protein kinase JAK2
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 14867.49 Å2
Buried surface area: 708.32 Å2
Dissociation area: 354.16 Å2
Dissociation energy (ΔGdiss): -2.42 kcal/mol
Dissociation entropy (TΔSdiss): 4.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130063

Macromolecules

Tyrosine-protein kinase JAK2
Chains: A, B
Length: 293 amino acids
Theoretical weight: 34.59 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60674 (Residues: 840-1132; Coverage: 26%)
Gene name: JAK2
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Tyrosine-protein kinase JAK2 in PDB entry 2b7a, assembly 1, front view.
Tyrosine-protein kinase JAK2 in PDB entry 2b7a, assembly 1, side view.
Tyrosine-protein kinase JAK2 in PDB entry 2b7a, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links