2b5i Summary


cytokine receptor complex

The structure was published by Wang, X., Rickert, M., and Garcia, K.C., in 2005 in a paper entitled "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This entry contains 12 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Interleukin-2 P60568 (21-153) (IL2_HUMAN)search Homo sapienssearch 98% 133 90%
B Interleukin-2 receptor beta chain P14784 (27-240) (IL2RB_HUMAN)search Homo sapienssearch < 90% 214 91%
C Cytokine receptor common gamma chain P31785 (56-254) (IL2RG_HUMAN)search Homo sapienssearch < 90% 199 95%
D Interleukin-2 receptor alpha chain P01589 (22-238) (IL2RA_HUMAN)search Homo sapienssearch < 90% 217 56%

This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P60568 (21 - 153) Interleukin-2 Homo sapiens
P14784 (27 - 240) Interleukin-2 receptor beta chain Homo sapiens
P31785 (56 - 254) Cytokine receptor common gamma chain Homo sapiens
P01589 (22 - 238) Interleukin-2 receptor alpha chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P60568) Short-chain cytokinessearch Growth Hormone; Chain: A;search PF00715: Interleukin 2search
B Fibronectin type IIIsearch Immunoglobulinssearch
C Fibronectin type IIIsearch Immunoglobulinssearch Fibronectin type III domainsearch, Interleukin-6 receptor alpha chain, bindingsearch
D Complement control module/SCR domainsearch Complement Module, domain 1search Sushi domain (SCR repeat)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P60568) interleukin-2 receptor bindingsearch growth factor activitysearch cytokine activitysearch carbohydrate bindingsearch kappa-type opioid receptor bindingsearch kinase activator activitysearch glycosphingolipid bindingsearch positive regulation of B cell proliferationsearch positive regulation of immunoglobulin secretionsearch positive regulation of interleukin-17 productionsearch positive regulation of isotype switching to IgG isotypessearch positive regulation of activated T cell proliferationsearch cell adhesionsearch negative regulation of lymphocyte proliferationsearch positive regulation of interferon-gamma productionsearch negative regulation of protein phosphorylationsearch positive regulation of tissue remodelingsearch positive regulation of inflammatory responsesearch positive regulation of cytosolic calcium ion concentrationsearch extrinsic apoptotic signaling pathway in absence of ligandsearch natural killer cell activationsearch positive regulation of tyrosine phosphorylation of Stat5 proteinsearch negative regulation of inflammatory responsesearch protein kinase C-activating G-protein coupled receptor signaling pathwaysearch positive regulation of cell proliferationsearch positive regulation of T cell proliferationsearch immune system processsearch positive regulation of dendritic spine developmentsearch regulation of T cell homeostatic proliferationsearch negative regulation of apoptotic processsearch immune responsesearch positive regulation of cell growthsearch G-protein coupled receptor signaling pathwaysearch positive regulation of regulatory T cell differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch T cell differentiationsearch positive regulation of protein phosphorylationsearch negative regulation of B cell apoptotic processsearch positive regulation of T cell differentiationsearch negative regulation of heart contractionsearch cell-cell signalingsearch extracellular regionsearch extracellular spacesearch
B (P14784) cytokine receptor activitysearch membranesearch
C (P31785) cytokine receptor activitysearch membranesearch

Chain InterPro annotation
A Interleukin-2search Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
B Short hematopoietin receptor, family 1, conserved sitesearch Fibronectin type IIIsearch Immunoglobulin-like foldsearch
C Short hematopoietin receptor, family 1, conserved sitesearch Fibronectin type IIIsearch Immunoglobulin-like foldsearch Interleukin-6 receptor alpha, bindingsearch
D Sushi/SCR/CCP domainsearch Interleukin-2 receptor alphasearch