2b5i Summary

pdbe.org/2b5i
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cytokine receptor complex

The structure was published by Wang, X., Rickert, M., and Garcia, K.C., in 2005 in a paper entitled "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This entry contains 12 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Interleukin-2 P60568 (21-153) (IL2_HUMAN)search Homo sapienssearch 99% 133 90%
B Interleukin-2 receptor beta chain P14784 (27-240) (IL2RB_HUMAN)search Homo sapienssearch < 90% 214 91%
C Cytokine receptor common gamma chain P31785 (56-254) (IL2RG_HUMAN)search Homo sapienssearch < 90% 199 95%
D Interleukin-2 receptor alpha chain P01589 (22-238) (IL2RA_HUMAN)search Homo sapienssearch < 90% 217 56%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P60568 (21 - 153) Interleukin-2 Homo sapiens
P14784 (27 - 240) Interleukin-2 receptor beta chain Homo sapiens
P31785 (56 - 254) Cytokine receptor common gamma chain Homo sapiens
P01589 (22 - 238) Interleukin-2 receptor alpha chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P60568) Short-chain cytokinessearch Growth Hormone; Chain: A;search PF00715: Interleukin 2search
B Fibronectin type IIIsearch
C Fibronectin type IIIsearch Fibronectin type III domainsearch, Interleukin-6 receptor alpha chain, bindingsearch
D Complement control module/SCR domainsearch Sushi domain (SCR repeat)search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P60568) negative regulation of lymphocyte proliferationsearch G-protein coupled receptor signaling pathwaysearch immune responsesearch positive regulation of dendritic spine developmentsearch negative regulation of inflammatory responsesearch positive regulation of interleukin-17 productionsearch positive regulation of tissue remodelingsearch cell-cell signalingsearch negative regulation of protein phosphorylationsearch positive regulation of cell growthsearch positive regulation of activated T cell proliferationsearch positive regulation of immunoglobulin secretionsearch positive regulation of interferon-gamma productionsearch positive regulation of T cell differentiationsearch positive regulation of cell proliferationsearch positive regulation of isotype switching to IgG isotypessearch positive regulation of regulatory T cell differentiationsearch positive regulation of inflammatory responsesearch positive regulation of tyrosine phosphorylation of Stat5 proteinsearch negative regulation of heart contractionsearch positive regulation of T cell proliferationsearch protein kinase C-activating G-protein coupled receptor signaling pathwaysearch regulation of T cell homeostatic proliferationsearch elevation of cytosolic calcium ion concentrationsearch negative regulation of apoptotic processsearch positive regulation of protein phosphorylationsearch natural killer cell activationsearch cell adhesionsearch T cell differentiationsearch negative regulation of B cell apoptotic processsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of B cell proliferationsearch kinase activator activitysearch growth factor activitysearch interleukin-2 receptor bindingsearch cytokine activitysearch kappa-type opioid receptor bindingsearch glycosphingolipid bindingsearch carbohydrate bindingsearch extracellular spacesearch extracellular regionsearch
B (P14784) cytokine receptor activitysearch membranesearch
C (P31785) cytokine receptor activitysearch membranesearch

Chain InterPro annotation
A Interleukin-2search Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
B Short hematopoietin receptor, family 1, conserved sitesearch Fibronectin, type IIIsearch Immunoglobulin-like foldsearch
C Short hematopoietin receptor, family 1, conserved sitesearch Fibronectin, type IIIsearch Immunoglobulin-like foldsearch Interleukin-6 receptor alpha, bindingsearch
D Sushi/SCR/CCPsearch Interleukin-2 receptor alphasearch