2b50 Summary


Human Nuclear Receptor-Ligand Complex 2

The structure was published by Fyffe, S.A., Alphey, M.S., Buetow, L., et al., Sorensen, M.D., Bjorkling, F., and Hunter, W.N., in 2006 in a paper entitled "Recombinant Human PPAR-beta/delta Ligand-binding Domain is Locked in an Activated Conformation by Endogenous Fatty Acids" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Peroxisome proliferator activated receptor delta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peroxisome proliferator activated receptor delta Q03181 (169-440) (PPARD_HUMAN)search Homo sapienssearch < 90% 272 96%
B Peroxisome proliferator activated receptor delta Q03181 (169-440) (PPARD_HUMAN)search Homo sapienssearch < 90% 272 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q03181 (169 - 440) Peroxisome proliferator activated receptor delta Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (Q03181) sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch steroid hormone receptor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Peroxisome proliferator-activated receptor, betasearch Nuclear hormone receptor, ligand-bindingsearch