2b4s Summary

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Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase

The structure was published by Li, S., Depetris, R.S., Barford, D., Chernoff, J., and Hubbard, S.R., in 2005 in a paper entitled "Crystal Structure of a Complex between Protein Tyrosine Phosphatase 1B and the Insulin Receptor Tyrosine Kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Tyrosine-protein phosphatase, non-receptor type 1 and Insulin receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein phosphatase, non-receptor type 1 P18031 (1-298) (PTN1_HUMAN)search Homo sapienssearch < 90% 298 96%
C Tyrosine-protein phosphatase, non-receptor type 1 P18031 (1-298) (PTN1_HUMAN)search Homo sapienssearch < 90% 298 96%
B Insulin receptor P06213 (1005-1310) (INSR_HUMAN)search Homo sapienssearch < 90% 306 97%
D Insulin receptor P06213 (1005-1310) (INSR_HUMAN)search Homo sapienssearch < 90% 306 97%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P18031 (1 - 298) Tyrosine-protein phosphatase, non-receptor type 1 Homo sapiens
P06213 (1005 - 1310) Insulin receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C Higher-molecular-weight phosphotyrosine protein phosphatasessearch Protein tyrosine phosphatase superfamilysearch Protein-tyrosine phosphatasesearch
B, D Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P18031) phosphatase activitysearch protein tyrosine phosphatase activitysearch protein dephosphorylationsearch dephosphorylationsearch
B, D (P06213) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch transmembrane receptor protein tyrosine kinase activitysearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A, C Protein-tyrosine phosphatase, receptor/non-receptor typesearch Protein-tyrosine/Dual specificity phosphatasesearch Protein-tyrosine phosphatase-likesearch
B, D Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch