Function and Biology Details
Reactions catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Tyrosine-specific protein phosphatase, PTPase domain
- Serine-threonine/tyrosine-protein kinase, catalytic domain
- Protein-tyrosine phosphatase-like
- Tyrosine-protein kinase, receptor class II, conserved site
- Tyrosine-protein kinase, active site
- Protein kinase, ATP binding site
- Tyrosine-protein kinase, catalytic domain
- Protein kinase domain
3 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138940 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type 1
Molecule details ›
Chains: A, C
Length: 298 amino acids
Theoretical weight: 34.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily
Length: 298 amino acids
Theoretical weight: 34.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P18031 (Residues: 1-298; Coverage: 69%)
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily
Insulin receptor subunit beta
Molecule details ›
Chains: B, D
Length: 306 amino acids
Theoretical weight: 35.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
Length: 306 amino acids
Theoretical weight: 35.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P06213 (Residues: 1005-1310; Coverage: 23%)
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
