Assemblies
Multimeric state:
hetero tetramer
Accessible surface area:
50321.73 Å2
Buried surface area:
6840.08 Å2
Dissociation area:
2,474.83
Å2
Dissociation energy (ΔGdiss):
-5.62
kcal/mol
Dissociation entropy (TΔSdiss):
40.95
kcal/mol
Symmetry number:
2
PDBe Complex ID:
PDB-CPX-138940
Macromolecules
Chains: A, C
Length: 298 amino acids
Theoretical weight: 34.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Pfam: Protein-tyrosine phosphatase
InterPro:
SCOP: Higher-molecular-weight phosphotyrosine protein phosphatases
Length: 298 amino acids
Theoretical weight: 34.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P18031 (Residues: 1-298; Coverage: 69%)
Pfam: Protein-tyrosine phosphatase
InterPro:
- Protein-tyrosine phosphatase-like
- Tyrosine-specific protein phosphatase, PTPase domain
- Protein-tyrosine phosphatase, catalytic
- Tyrosine-specific protein phosphatases domain
SCOP: Higher-molecular-weight phosphotyrosine protein phosphatases
Chains: B, D
Length: 306 amino acids
Theoretical weight: 35.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
SCOP: Protein kinases, catalytic subunit
Length: 306 amino acids
Theoretical weight: 35.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P06213 (Residues: 1005-1310; Coverage: 23%)
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
- Protein kinase-like domain superfamily
- Protein kinase domain
- Serine-threonine/tyrosine-protein kinase, catalytic domain
- Tyrosine-protein kinase, catalytic domain
- Protein kinase, ATP binding site
- Tyrosine-protein kinase, active site
- Tyrosine-protein kinase, receptor class II, conserved site
SCOP: Protein kinases, catalytic subunit
