Function and Biology

Crystal structure of a papain-fold protein without the catalytic cysteine from seeds of Pachyrhizus erosus

Source organism: Pachyrhizus erosus
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis involved in protein catabolic process
Cellular component: lysosome

Sequence family

Pfam Protein family (Pfam)
PF00112
Domain description: Papain family cysteine protease
Occurring in:
  1. Peptidase C1A papain C-terminal domain-containing protein
The deposited structure of PDB entry 2b1n contains 1 copy of Pfam domain PF00112 (Papain family cysteine protease) in Peptidase C1A papain C-terminal domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000668
Domain description: Peptidase C1A, papain C-terminal
Occurring in:
  1. Peptidase C1A papain C-terminal domain-containing protein
IPR025661
Domain description: Cysteine peptidase, asparagine active site
Occurring in:
  1. Peptidase C1A papain C-terminal domain-containing protein
IPR013128
Domain description: Peptidase C1A
Occurring in:
  1. Peptidase C1A papain C-terminal domain-containing protein
IPR039417
Domain description: Papain-like cysteine endopeptidase
Occurring in:
  1. Peptidase C1A papain C-terminal domain-containing protein
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Peptidase C1A papain C-terminal domain-containing protein

Structure domain

CATH CATH domain
3.90.70.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Cathepsin B; Chain A
Homology: Cysteine proteinases
Occurring in:
  1. Peptidase C1A papain C-terminal domain-containing protein
The deposited structure of PDB entry 2b1n contains 1 copy of CATH domain 3.90.70.10 (Cathepsin B; Chain A) in Peptidase C1A papain C-terminal domain-containing protein. Showing 1 copy in chain A.