› › Function and Biology

Crystal Structure Of 3',5"-Aminoglycoside Phosphotransferase Type IIIa ADP Neomycin B Complex

Source organism: Enterococcus faecalis
Biochemical function: phosphotransferase activity, alcohol group as acceptor
Biological process: response to antibiotic
Cellular component: not assigned

Quick links

EC 2.7.1.95: Kanamycin kinase

Reaction catalysed:
ATP + kanamycin = ADP + kanamycin 3'-phosphate
Systematic name:
ATP:kanamycin 3'-O-phosphotransferase
Alternative Name(s):
  • APH(3')
  • Aminoglycoside 3'-phosphotransferase
  • Kanamycin kinase (phosphorylating)
  • Neomycin phosphotransferase
  • Neomycin-kanamycin phosphotransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01636
Domain description: Phosphotransferase enzyme family
Occurring in:
  1. Aminoglycoside 3'-phosphotransferase
The deposited structure of PDB entry 2b0q contains 1 copy of Pfam domain PF01636 (Phosphotransferase enzyme family) in Aminoglycoside 3'-phosphotransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR024165
Domain description: Aminoglycoside 3-phosphotransferase
Occurring in:
  1. Aminoglycoside 3'-phosphotransferase
IPR002575
Domain description: Aminoglycoside phosphotransferase
Occurring in:
  1. Aminoglycoside 3'-phosphotransferase
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Aminoglycoside 3'-phosphotransferase

Structure domains

CATH CATH domains
3.90.1200.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2
Homology: Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2
Occurring in:
  1. Aminoglycoside 3'-phosphotransferase
The deposited structure of PDB entry 2b0q contains 1 copy of CATH domain 3.90.1200.10 (Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2) in Aminoglycoside 3'-phosphotransferase. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Aminoglycoside 3'-phosphotransferase
The deposited structure of PDB entry 2b0q contains 1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Aminoglycoside 3'-phosphotransferase. Showing 1 copy in chain A.
SCOP SCOP annotation
64411
Class: Alpha and beta proteins (a+b)
Fold: Protein kinase-like (PK-like)
Superfamily: Protein kinase-like (PK-like)
Occurring in:
  1. Aminoglycoside 3'-phosphotransferase
The deposited structure of PDB entry 2b0q contains 1 copy of SCOP domain 64411 (APH phosphotransferases) in Aminoglycoside 3'-phosphotransferase. Showing 1 copy in chain A.

Quick links