2az5 Summary

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Crystal Structure of TNF-alpha with a small molecule inhibitor

The structure was published by He, M.M., Smith, A.S., Oslob, J.D., et al., Friedman, J.E., Choong, I.C., and Cunningham, B.C., in 2005 in a paper entitled "Small-molecule inhibition of TNF-alpha." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form].

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form] P01375 (86-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 148 95%
B Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form] P01375 (86-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 148 95%
C Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form] P01375 (86-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 148 95%
D Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form] P01375 (86-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 148 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01375 (86 - 233) Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form] Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D TNF-likesearch Jelly Rollssearch TNF(Tumour Necrosis Factor) familysearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, D (P01375) immune responsesearch apoptotic processsearch signal transductionsearch membranesearch extracellular regionsearch tumor necrosis factor receptor bindingsearch

Chain InterPro annotation
A, B, C, D Tumour necrosis factor alphasearch Tumour necrosis factor domainsearch Tumour necrosis factorsearch Tumour necrosis factor alpha/TNFSF15search Tumour necrosis factor-like domainsearch Tumour necrosis factor, conserved sitesearch