A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats
The structure was published by Hummel, C.W., Geiser, A.G., Bryant, H.U., et al., Wallace, O.B., Wang, Y., and Dodge, J.A., in 2005 in a paper entitled "A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2005.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Estrogen receptor. This molecule has the UniProt identifier P03372 (ESR1_HUMAN). The sample contained 248 residues which is < 90% of the natural sequence. Out of 248 residues 245 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: